PF3D7_1440400

Genome location: Pf3D7_14_v3:1,647,006..1,652,199(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.16	0.91
Schizont	not expressed	0.82	0.58
Gametocyte	not expressed	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1440400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.967 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1304300)

Relative Growth Rate: 0.13 ± 0.08
Confidence: 6.50

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL66

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105580

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	69	42	75
disruptive	40	172	89	231
missense	28	162	80	195

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	136	66	80
disruptive	74	361	149	324
missense	52	312	125	242

PlasmoDB Total SNPs: 236

Non-coding: 135 | Synonymous: 53 | Nonsynonymous: 48 | Stop Codon: 0

Protein Information

Protein Length: 1280 | Molecular Weight (kDa): 152.797

UniProt ID(s): Q8IL66, Q95Z58

PDB ID(s): None

Isoelectric Point: 7.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000315	B-box-type zinc finger
PFam	N/A	N/A
Superfamily	SSF57845	N/A