Product Description: allantoicase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.5.3.4 (Allantoicase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0004037 | allantoicase activity |
| Process | GO:0000256 | allantoin catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.11 | 0.94 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.31 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1440500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.154 | #Insertions: 11
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1304400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1304400)
Modification: Disrupted | RMgm-3423
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL65
"Best" AlphaFill ligand hit: NDP (nadph dihydro-nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.90) with 7XWU (Global RMSD=21.28)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.5.3.4 | allantoicase | EDTANH4+phosphateAllantoateiodoacetateL-asparagineglycolic acidHydantoic acidN-Acetylimidazolediethyldicarbonate(-)-ureidoglycolatep-hydroxymercuribenzoate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105441
Most Similar Human Ortholog: Q8N6M5
TM-align score: 0.73 | RMSD: 4.01
Seq Identity: 0.23 | Length: 350 / 553
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000151360 | allantoicase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 36 | 25 | 45 |
| disruptive | 5 | 30 | 25 | 57 |
| missense | 5 | 29 | 23 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 83 | 28 | 49 |
| disruptive | 17 | 85 | 38 | 113 |
| missense | 11 | 72 | 28 | 86 |
PlasmoDB Total SNPs: 58
Non-coding: 22 | Synonymous: 29 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 553 | Molecular Weight (kDa): 64.799
UniProt ID(s): Q8IL65
PDB ID(s): None
Isoelectric Point: 7.9
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005164 | Allantoicase |
| InterPro | IPR008979 | Galactose-binding-like domain superfamily |
| InterPro | IPR015908 | Allantoicase domain |
| PFam | PF03561 | Allantoicase domain |
| Superfamily | SSF49785 | Galactose-binding-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |