About Gene List

PF3D7_1440600 (SOC3)

Genome location: Pf3D7_14_v3:1,656,288..1,660,015(+)

Genome classification: Core

Function and Localization

Product Description: protein SOC3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005930 axoneme

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite not expressed 0.04 0.98
Schizont not expressed 0.02 0.99
Gametocyte not expressed 0.78 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1440600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.918 | MFS: -2.344 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1304500)

  • Relative Growth Rate: 0.92 ± 0.15
  • Confidence: 5.17

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1304500)

Modification: Tagged | RMgm-4153

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A207

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.23) with 6JWQ (Global RMSD=35.92)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533752

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 25 13 37
disruptive 10 30 19 63
missense 10 30 19 59

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 49 21 38
disruptive 12 84 45 94
missense 11 69 44 69

PlasmoDB Total SNPs: 213

Non-coding: 180 | Synonymous: 24 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 463 | Molecular Weight (kDa): 55.493

UniProt ID(s): A0A144A207

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
28481199 Multiple short windows of calcium-dependent protein kinase 4 activity coordinatedistinct cell cycle events during Plasmodium gametogenesis Fang H, Klages N, ..., Brochet M 10.7554/eLife.26524