PF3D7_1440700 (AP3M)

Genome location: Pf3D7_14_v3:1,659,431..1,663,587(-)

Genome classification: Core

Function and Localization

Product Description: AP-3 complex subunit mu, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030123	AP-3 adaptor complex
Component	GO:0031410	cytoplasmic vesicle
Component	GO:0043231	intracellular membrane-bounded organelle
Process	GO:0006897	endocytosis
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.07	0.96
Trophozoite	expressed	0.33	0.80
Schizont	expressed	0.25	0.83
Gametocyte	expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1440700

Resistome Missense Mutations: F153L

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 8 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.099 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1304600)

Relative Growth Rate: 0.09 ± 0.16
Confidence: 5.04

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL63

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532933

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	22	15	43
disruptive	15	64	44	133
missense	10	58	42	126

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	55	26	51
disruptive	26	166	94	228
missense	18	142	83	173

PlasmoDB Total SNPs: 154

Non-coding: 99 | Synonymous: 42 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 733 | Molecular Weight (kDa): 87.166

UniProt ID(s): Q8IL63

PDB ID(s): None

Isoelectric Point: 8.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011012	Longin-like domain superfamily
InterPro	IPR028565	Mu homology domain
InterPro	IPR036168	AP-2 complex subunit mu, C-terminal superfamily
PFam	PF00928	Mu homology domain
Superfamily	SSF49447	AP-2 complex subunit mu, C-terminal superfamily
Superfamily	SSF64356	Longin-like domain superfamily