About Gene List

PF3D7_1440900

Genome location: Pf3D7_14_v3:1,668,319..1,670,272(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.02 0.99
Trophozoite not expressed 0.01 0.99
Schizont expressed 0.79 0.61
Gametocyte expressed 0.33 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1440900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -2.969 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1304800)

  • Relative Growth Rate: 0.99 ± 0.18
  • Confidence: 4.81

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1304800)

Modification: Disrupted | RMgm-3427

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL61

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533683

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 7 9 10
disruptive 9 13 7 55
missense 9 11 6 52

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 18 6 17
disruptive 14 38 23 63
missense 10 35 20 54

PlasmoDB Total SNPs: 66

Non-coding: 53 | Synonymous: 6 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 234 | Molecular Weight (kDa): 28.252

UniProt ID(s): Q8IL61

PDB ID(s): None

Isoelectric Point: 7.77

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34956931 Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening ofPlasmodium falciparum. Hou N, Li S, ..., Chen Q https://pubmed.ncbi.nlm.nih.gov/34956931/