About Gene List

PF3D7_1441200

Genome location: Pf3D7_14_v3:1,677,565..1,680,894(+)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit
Component GO:0005622 intracellular
Component GO:0005634 nucleus
Function GO:0003723 RNA binding
Function GO:0003735 structural constituent of ribosome
Process GO:0000470 maturation of LSU-rRNA
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.77 0.65
Trophozoite expressed 1.10 0.46
Schizont expressed 0.14 0.91
Gametocyte expressed 0.42 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1441200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.37 | MFS: -3.314 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1305100)

  • Relative Growth Rate: 0.06 ± 0.07
  • Confidence: 6.83

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_1308900)

Modification: Tagged | RMgm-1562

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL58

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100869

Most Similar Human Ortholog: P62906

TM-align score: 0.97 | RMSD: 1.00

Seq Identity: 0.63 | Length: 216 / 217

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000198755 ribosomal protein L10a

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 119

Non-coding: 115 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 217 | Molecular Weight (kDa): 24.805

UniProt ID(s): Q8IL58

PDB ID(s): None

Isoelectric Point: 10.57

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002143 Ribosomal protein L1
InterPro IPR023674 Ribosomal protein L1-like
InterPro IPR028364 Ribosomal protein L1/ribosomal biogenesis protein
PFam PF00687 Ribosomal protein L1/ribosomal biogenesis protein
Superfamily SSF56808 Ribosomal protein L1-like

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27503796 Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. Siau A, Huang X, ..., Preiser PR 10.1038/srep31055
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596