Genome location: Pf3D7_14_v3:1,690,768..1,693,319(+)
Genome classification: Core
Product Description: FACT complex subunit SSRP1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0035101 | FACT complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0042393 | histone binding |
| Function | GO:0031491 | nucleosome binding |
| Function | GO:0003697 | single-stranded DNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.24 | 0.84 |
| Schizont | expressed | 0.05 | 0.96 |
| Gametocyte | expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1441400
Resistome Missense Mutations: Q194H
Resistome Compounds with Missense Mutations: Desoxyepothilone B
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.034 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1305300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL56
"Best" AlphaFill ligand hit: NDP (nadph dihydro-nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.04) with 3JSU (Global RMSD=13.70)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101807
Most Similar Human Ortholog: E9PPZ7
TM-align score: 0.85 | RMSD: 1.77
Seq Identity: 0.28 | Length: 88 / 506
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000149136 | structure specific recognition protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 32 | 10 | 38 |
| disruptive | 6 | 18 | 24 | 47 |
| missense | 3 | 14 | 20 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 63 | 34 | 34 |
| disruptive | 10 | 71 | 48 | 127 |
| missense | 5 | 55 | 30 | 79 |
PlasmoDB Total SNPs: 86
Non-coding: 61 | Synonymous: 16 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 506 | Molecular Weight (kDa): 58.787
UniProt ID(s): Q8IL56
PDB ID(s): None
Isoelectric Point: 4.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000969 | Structure-specific recognition protein |
| InterPro | IPR013719 | Domain of unknown function DUF1747 |
| InterPro | IPR024954 | SSRP1 domain |
| InterPro | IPR035417 | FACT complex subunit POB3-like, N-terminal PH domain |
| PFam | PF03531 | SSRP1 domain |
| PFam | PF08512 | Domain of unknown function DUF1747 |
| PFam | PF17292 | FACT complex subunit POB3-like, N-terminal PH domain |
| Superfamily | SSF50729 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 30679261 | Establishment and Maintenance of Chromatin Architecture Are PromotedIndependently of Transcription by the Histone Chaperone FACT and H3-K56Acetylation in Saccharomyces cerevisiae | McCullough LL, Pham TH, ..., Formosa T | 10.1534/genetics.118.301853 |