About Gene List

PF3D7_1441500

Genome location: Pf3D7_14_v3:1,692,760..1,695,638(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.17 0.91
Trophozoite expressed 0.69 0.62
Schizont possibly expressed 0.47 0.72
Gametocyte possibly expressed 0.51 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1441500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.973 | MFS: -2.662 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL55

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533720

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 30 15 36
disruptive 9 31 20 53
missense 8 26 18 50

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 57 13 42
disruptive 23 74 44 98
missense 14 62 32 73

PlasmoDB Total SNPs: 88

Non-coding: 63 | Synonymous: 16 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 485 | Molecular Weight (kDa): 58.371

UniProt ID(s): Q8IL55

PDB ID(s): None

Isoelectric Point: 10.19

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008614 Acidic fibroblast growth factor intracellular-binding protein
PFam PF05427 Acidic fibroblast growth factor intracellular-binding protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094