PF3D7_1441600

Genome location: Pf3D7_14_v3:1,696,250..1,698,728(-)

Genome classification: Core

Function and Localization

Product Description: acid cluster protein 33 homologue, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.08	0.94
Schizont	not expressed	0.13	0.90
Gametocyte	not expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1441600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.496 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL54

"Best" AlphaFill ligand hit: PPI (propanoic acid, Local RMSD=0.83) with 1UK6 (Global RMSD=2.54)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105553

Most Similar Human Ortholog: H0YMB7

TM-align score: 0.88 | RMSD: 1.31

Seq Identity: 0.37 | Length: 133 / 569

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000090487	SPG21 abhydrolase domain containing, maspardin

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	45	14	38
disruptive	12	71	32	86
missense	11	65	31	77

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	64	27	47
disruptive	26	156	68	153
missense	22	137	51	98

PlasmoDB Total SNPs: 99

Non-coding: 67 | Synonymous: 20 | Nonsynonymous: 11 | Stop Codon: 1

Protein Information

Protein Length: 569 | Molecular Weight (kDa): 67.622

UniProt ID(s): Q8IL54

PDB ID(s): None

Isoelectric Point: 6.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000073	Alpha/beta hydrolase fold-1
InterPro	IPR026151	Maspardin
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	PF00561	Alpha/beta hydrolase fold-1
Superfamily	SSF53474	Alpha/Beta hydrolase fold