Genome location: Pf3D7_14_v3:1,702,306..1,704,179(-)
Genome classification: Core
Product Description: vacuolar protein sorting-associated protein 60, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005771 | multivesicular body |
| Process | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway |
| Process | GO:0006900 | vesicle budding from membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.96 |
| Trophozoite | possibly expressed | 0.50 | 0.70 |
| Schizont | possibly expressed | 0.27 | 0.83 |
| Gametocyte | expressed | 0.53 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1441800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.401 | #Insertions: 3
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0800700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A3Q5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102352
Most Similar Human Ortholog: Q9NZZ3
TM-align score: 0.55 | RMSD: 3.10
Seq Identity: 0.23 | Length: 138 / 229
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000086065 | charged multivesicular body protein 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 2 | 11 |
| disruptive | 3 | 22 | 13 | 29 |
| missense | 3 | 22 | 11 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 19 | 9 | 13 |
| disruptive | 9 | 49 | 27 | 55 |
| missense | 4 | 41 | 21 | 38 |
PlasmoDB Total SNPs: 95
Non-coding: 84 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 229 | Molecular Weight (kDa): 26.757
UniProt ID(s): A0A144A3Q5, Q8IL52
PDB ID(s): None
Isoelectric Point: 4.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005024 | Snf7 family |
| PFam | PF03357 | Snf7 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 27924850 | NMR studies on the interactions between yeast Vta1 and Did2 during themultivesicular bodies sorting pathway | Shen J, Yang Z, ..., Cao C | 10.1038/srep38710 |