Product Description: ADP-ribosylation factor, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0015630 | microtubule cytoskeleton |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003924 | GTPase activity |
| Process | GO:0031116 | positive regulation of microtubule polymerization |
| Process | GO:0006471 | protein ADP-ribosylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.04 | 0.97 |
| Schizont | expressed | 0.00 | 1.00 |
| Gametocyte | expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1442000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -2.82 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL50
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.09) with 3NKV (Global RMSD=4.08)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103223
Most Similar Human Ortholog: P36404
TM-align score: 0.91 | RMSD: 0.89
Seq Identity: 0.55 | Length: 170 / 183
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000213465 | ADP ribosylation factor like GTPase 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 13 | 6 | 11 |
| disruptive | 0 | 8 | 8 | 20 |
| missense | 0 | 8 | 8 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 22 | 8 | 11 |
| disruptive | 1 | 18 | 12 | 28 |
| missense | 1 | 18 | 11 | 24 |
PlasmoDB Total SNPs: 42
Non-coding: 29 | Synonymous: 13 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 183 | Molecular Weight (kDa): 21.235
UniProt ID(s): Q8IL50
PDB ID(s): None
Isoelectric Point: 6.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005225 | Small GTP-binding protein domain |
| InterPro | IPR006689 | Small GTPase superfamily, ARF/SAR type |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00025 | Small GTPase superfamily, ARF/SAR type |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 18452584 | Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase genecauses aberrant gametogenesis. | Taylor CJ, McRobert L, Baker DA | 10.1111/j.1365-2958.2008.06267.x |