Genome location: Pf3D7_14_v3:1,708,390..1,712,078(-)
Genome classification: Core
Product Description: GTP-binding protein YihA2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0097177 | mitochondrial ribosome binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.14 | 0.93 |
| Trophozoite | possibly expressed | 0.33 | 0.80 |
| Schizont | possibly expressed | 0.11 | 0.93 |
| Gametocyte | possibly expressed | 0.35 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1442200
Resistome Missense Mutations: K294I
Resistome Compounds with Missense Mutations: BCH070
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.998 | MFS: -2.515 | #Insertions: 2
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1306100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL49
"Best" AlphaFill ligand hit: DXC ((3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid, Local RMSD=0.24) with 4AC9 (Global RMSD=5.13)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101142
Most Similar Human Ortholog: C9J0K3
TM-align score: 0.91 | RMSD: 1.59
Seq Identity: 0.28 | Length: 132 / 1000
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000163607 | GTP binding protein 8 (putative) |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 53 | 28 | 72 |
| disruptive | 20 | 138 | 88 | 196 |
| missense | 18 | 133 | 86 | 175 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 93 | 51 | 73 |
| disruptive | 50 | 282 | 140 | 231 |
| missense | 41 | 255 | 124 | 188 |
PlasmoDB Total SNPs: 174
Non-coding: 81 | Synonymous: 58 | Nonsynonymous: 35 | Stop Codon: 0
Protein Length: 1000 | Molecular Weight (kDa): 118.657
UniProt ID(s): Q8IL49
PDB ID(s): None
Isoelectric Point: 9.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006073 | GTP binding domain |
| InterPro | IPR019987 | GTP-binding protein, ribosome biogenesis, YsxC |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR030393 | EngB-type guanine nucleotide-binding (G) domain |
| PFam | PF01926 | GTP binding domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32057832 | YihA GTPases localize to the apicoplast and mitochondrion of the malaria parasiteand interact with LSU of organellar ribosomes. | Gupta A, Gupta K, Habib S | 10.1016/j.molbiopara.2020.111265 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |