About Gene List

PF3D7_1442600 (TREP)

Genome location: Pf3D7_14_v3:1,730,087..1,740,916(+)

Genome classification: Core

Function and Localization

Product Description: TRAP-like protein

SignalP Peptide: MNFFSIFIILNFFMLSLT

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite possibly expressed 0.13 0.93
Schizont not expressed 0.04 0.98
Gametocyte not expressed 0.22 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1442600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.542 | #Insertions: 11

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1306500)

Modification: Disrupted | RMgm-5107

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_114813

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 28 116 81 188
disruptive 151 569 271 645
missense 120 505 243 537

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 51 222 110 209
disruptive 265 979 415 771
missense 208 839 360 569

PlasmoDB Total SNPs: 1052

Non-coding: 16 | Synonymous: 465 | Nonsynonymous: 569 | Stop Codon: 2

Protein Information

Protein Length: 3543 | Molecular Weight (kDa): 412.691

UniProt ID(s): Q8IL45

PDB ID(s): None

Isoelectric Point: 4.54

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
34717635 Limited Plasmodium sporozoite gliding motility in the absence of TRAP familyadhesins Beyer K, Kracht S, ..., Frischknecht F 10.1186/s12936-021-03960-3