Genome location: Pf3D7_14_v3:1,730,087..1,740,916(+)
Genome classification: Core
Product Description: TRAP-like protein
SignalP Peptide: MNFFSIFIILNFFMLSLT
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.08 | 0.96 |
Trophozoite | possibly expressed | 0.13 | 0.93 |
Schizont | not expressed | 0.04 | 0.98 |
Gametocyte | not expressed | 0.22 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1442600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.542 | #Insertions: 11
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1306500)
Modification: Disrupted | RMgm-5107
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 28 | 116 | 81 | 188 |
disruptive | 151 | 569 | 271 | 645 |
missense | 120 | 505 | 243 | 537 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 51 | 222 | 110 | 209 |
disruptive | 265 | 979 | 415 | 771 |
missense | 208 | 839 | 360 | 569 |
PlasmoDB Total SNPs: 1052
Non-coding: 16 | Synonymous: 465 | Nonsynonymous: 569 | Stop Codon: 2
Protein Length: 3543 | Molecular Weight (kDa): 412.691
UniProt ID(s): Q8IL45
PDB ID(s): None
Isoelectric Point: 4.54
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
34717635 | Limited Plasmodium sporozoite gliding motility in the absence of TRAP familyadhesins | Beyer K, Kracht S, ..., Frischknecht F | 10.1186/s12936-021-03960-3 |