PF3D7_1442700

Genome location: Pf3D7_14_v3:1,742,097..1,750,189(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	possibly expressed	0.79	0.60
Schizont	expressed	0.66	0.66
Gametocyte	not expressed	1.00	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1442700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.505 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL44

"Best" AlphaFill ligand hit: RHQ (rhodamine 6g, Local RMSD=2.56) with 3BR5 (Global RMSD=42.67)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532476

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	105	66	170
disruptive	103	466	254	603
missense	91	438	245	541

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	33	226	106	187
disruptive	202	882	383	653
missense	155	807	350	544

PlasmoDB Total SNPs: 273

Non-coding: 42 | Synonymous: 100 | Nonsynonymous: 128 | Stop Codon: 3

Protein Information

Protein Length: 2511 | Molecular Weight (kDa): 300.98

UniProt ID(s): Q8IL44

PDB ID(s): None

Isoelectric Point: 9.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A