About Gene List

PF3D7_1442700

Genome location: Pf3D7_14_v3:1,742,097..1,750,189(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite possibly expressed 0.79 0.60
Schizont expressed 0.66 0.66
Gametocyte not expressed 1.00 0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1442700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.505 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL44

"Best" AlphaFill ligand hit: RHQ (rhodamine 6g, Local RMSD=2.56) with 3BR5 (Global RMSD=42.67)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532476

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 105 66 170
disruptive 103 466 254 603
missense 91 438 245 541

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 33 226 106 187
disruptive 202 882 383 653
missense 155 807 350 544

PlasmoDB Total SNPs: 273

Non-coding: 42 | Synonymous: 100 | Nonsynonymous: 128 | Stop Codon: 3

Protein Information

Protein Length: 2511 | Molecular Weight (kDa): 300.98

UniProt ID(s): Q8IL44

PDB ID(s): None

Isoelectric Point: 9.62

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097