PF3D7_1442800

Genome location: Pf3D7_14_v3:1,750,209..1,751,417(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005759	mitochondrial matrix
Function	GO:0003746	translation elongation factor activity
Process	GO:0070125	mitochondrial translational elongation
Process	GO:0006414	translational elongation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.95
Trophozoite	not expressed	0.17	0.89
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1442800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.184 | MFS: -2.961 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1306700)

Relative Growth Rate: 1.03 ± 0.18
Confidence: 4.79

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1306700)

Modification: Disrupted | RMgm-3436

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL43

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.13) with 3UM6 (Global RMSD=19.87)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533595

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	22	5	24
disruptive	12	55	36	82
missense	12	53	35	80

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	32	17	25
disruptive	22	127	62	103
missense	17	114	55	85

PlasmoDB Total SNPs: 39

Non-coding: 0 | Synonymous: 16 | Nonsynonymous: 21 | Stop Codon: 2

Protein Information

Protein Length: 402 | Molecular Weight (kDa): 48.296

UniProt ID(s): Q8IL43

PDB ID(s): None

Isoelectric Point: 8.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001816	Translation elongation factor EFTs/EF1B
PFam	N/A	N/A
Superfamily	N/A	N/A