Genome location: Pf3D7_14_v3:1,769,337..1,772,421(-)
Genome classification: Core
Product Description: apicomplexan kinetochore protein 9, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000776 | kinetochore |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.64 | 0.64 |
| Schizont | expressed | 0.84 | 0.55 |
| Gametocyte | expressed | 0.96 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1443100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.129 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1307000)
Modification: Tagged | RMgm-5121
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL40
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 26 | 18 | 28 |
| disruptive | 26 | 57 | 27 | 87 |
| missense | 24 | 51 | 26 | 79 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 42 | 21 | 40 |
| disruptive | 45 | 124 | 65 | 164 |
| missense | 38 | 94 | 54 | 117 |
PlasmoDB Total SNPs: 99
Non-coding: 45 | Synonymous: 27 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 574 | Molecular Weight (kDa): 67.604
UniProt ID(s): Q8IL40
PDB ID(s): None
Isoelectric Point: 8.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 36006241 | Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation | Brusini L, Dos Santos Pacheco N, ..., Brochet M | 10.1083/jcb.202111084 |