About Gene List

PF3D7_1443200

Genome location: Pf3D7_14_v3:1,772,462..1,775,197(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.03 0.99
Trophozoite expressed 0.13 0.92
Schizont expressed 0.04 0.97
Gametocyte expressed 0.15 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1443200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.177 | MFS: -3.321 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1307100)

  • Relative Growth Rate: 0.06 ± 0.04
  • Confidence: 7.97

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL39

"Best" AlphaFill ligand hit: CHT (choline ion, Local RMSD=0.60) with 3C5I (Global RMSD=15.74)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533350

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 33 18 36
disruptive 11 41 51 102
missense 11 38 51 90

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 58 30 44
disruptive 16 148 64 177
missense 14 123 60 117

PlasmoDB Total SNPs: 80

Non-coding: 37 | Synonymous: 26 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 596 | Molecular Weight (kDa): 71.039

UniProt ID(s): Q8IL39

PDB ID(s): None

Isoelectric Point: 9.49

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108