Genome location: Pf3D7_14_v3:1,776,703..1,780,208(-)
Genome classification: Core
Product Description: WD repeat-containing protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.67 | 0.62 |
| Schizont | expressed | 0.38 | 0.76 |
| Gametocyte | possibly expressed | 0.35 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1443400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.252 | MFS: -2.75 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL37
"Best" AlphaFill ligand hit: NAD (nicotinamide-adenine-dinucleotide, Local RMSD=23.00) with 4WUV (Global RMSD=21.90)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 44 | 28 | 51 |
| disruptive | 27 | 119 | 75 | 142 |
| missense | 20 | 114 | 71 | 123 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 95 | 42 | 58 |
| disruptive | 45 | 250 | 95 | 225 |
| missense | 37 | 215 | 81 | 155 |
PlasmoDB Total SNPs: 161
Non-coding: 79 | Synonymous: 36 | Nonsynonymous: 46 | Stop Codon: 0
Protein Length: 819 | Molecular Weight (kDa): 95.825
UniProt ID(s): Q8IL37
PDB ID(s): None
Isoelectric Point: 6.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| InterPro | IPR037588 | Target of rapamycin complex subunit LST8 |
| PFam | N/A | N/A |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 26537493 | A WD40-repeat protein unique to malaria parasites associates with adhesionprotein complexes and is crucial for blood stage progeny. | von Bohl A, Kuehn A, ..., Pradel G | 10.1186/s12936-015-0967-x |