Product Description: gamma-tubulin complex component, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005813 | centrosome |
| Component | GO:0000923 | equatorial microtubule organizing center |
| Component | GO:0000930 | gamma-tubulin complex |
| Component | GO:0008275 | gamma-tubulin small complex |
| Function | GO:0043015 | gamma-tubulin binding |
| Process | GO:0031122 | cytoplasmic microtubule organization |
| Process | GO:0051321 | meiotic cell cycle |
| Process | GO:0051415 | microtubule nucleation by interphase microtubule organizing center |
| Process | GO:0000278 | mitotic cell cycle |
| Process | GO:0051225 | spindle assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | not expressed | 0.68 | 0.62 |
| Schizont | not expressed | 0.32 | 0.80 |
| Gametocyte | not expressed | 0.64 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1443600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.099 | #Insertions: 4
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0402100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL35
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103557
Most Similar Human Ortholog: H3BNL9
TM-align score: 0.84 | RMSD: 2.47
Seq Identity: 0.20 | Length: 168 / 1898
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137822 | tubulin gamma complex associated protein 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 92 | 57 | 103 |
| disruptive | 26 | 185 | 122 | 265 |
| missense | 17 | 177 | 116 | 251 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 32 | 183 | 93 | 107 |
| disruptive | 58 | 413 | 177 | 409 |
| missense | 40 | 377 | 154 | 325 |
PlasmoDB Total SNPs: 106
Non-coding: 0 | Synonymous: 66 | Nonsynonymous: 40 | Stop Codon: 0
Protein Length: 1898 | Molecular Weight (kDa): 223.83
UniProt ID(s): Q8IL35
PDB ID(s): None
Isoelectric Point: 6.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007259 | Gamma-tubulin complex component protein |
| InterPro | IPR040457 | Gamma tubulin complex component, C-terminal |
| InterPro | IPR041470 | Gamma tubulin complex component protein, N-terminal |
| PFam | PF04130 | Gamma tubulin complex component, C-terminal |
| PFam | PF17681 | Gamma tubulin complex component protein, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |