Genome location: Pf3D7_14_v3:1,794,369..1,796,682(-)
Genome classification: Core
Product Description: pre-mRNA-splicing factor CWC24, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005684 | U2-type spliceosomal complex |
| Component | GO:0005681 | spliceosomal complex |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0034247 | snoRNA splicing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.17 | 0.91 |
| Trophozoite | expressed | 0.45 | 0.73 |
| Schizont | expressed | 0.14 | 0.90 |
| Gametocyte | expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1443800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.101 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL33
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102529
Most Similar Human Ortholog: O15541
TM-align score: 0.29 | RMSD: 4.73
Seq Identity: 0.37 | Length: 132 / 408
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000125352 | ring finger protein 113A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 17 | 7 | 21 |
| disruptive | 4 | 49 | 30 | 63 |
| missense | 4 | 48 | 29 | 55 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 26 | 14 | 28 |
| disruptive | 16 | 114 | 54 | 133 |
| missense | 9 | 101 | 42 | 85 |
PlasmoDB Total SNPs: 88
Non-coding: 67 | Synonymous: 16 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 408 | Molecular Weight (kDa): 48.091
UniProt ID(s): Q8IL33
PDB ID(s): None
Isoelectric Point: 8.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000571 | Zinc finger, CCCH-type |
| InterPro | IPR036855 | Zinc finger, CCCH-type superfamily |
| InterPro | IPR039971 | Pre-mRNA-splicing factor CWC24-like |
| PFam | PF00642 | Zinc finger, CCCH-type |
| Superfamily | SSF57850 | Zinc finger, CCCH-type superfamily |
| Superfamily | SSF90229 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27445306 | Structure of a yeast activated spliceosome at 3.5 A resolution | Yan C, Wan R, ..., Shi Y | 10.1126/science.aag0291 |