Genome location: Pf3D7_14_v3:1,797,266..1,800,666(+)
Genome classification: Core
Product Description: heat shock protein 90, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0048471 | perinuclear region of cytoplasm |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006457 | protein folding |
| Process | GO:0009408 | response to heat |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.36 | 0.84 |
| Trophozoite | expressed | 1.71 | 0.26 |
| Schizont | expressed | 0.55 | 0.70 |
| Gametocyte | expressed | 0.80 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1443900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.135 | MFS: -3.033 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1307800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL32
"Best" AlphaFill ligand hit: RDC (monorden, Local RMSD=0.52) with 4EGK (Global RMSD=8.00)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 63 | 32 | 65 |
| disruptive | 7 | 47 | 36 | 74 |
| missense | 7 | 45 | 34 | 64 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 133 | 37 | 39 |
| disruptive | 17 | 113 | 44 | 123 |
| missense | 13 | 99 | 36 | 96 |
PlasmoDB Total SNPs: 111
Non-coding: 77 | Synonymous: 22 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 927 | Molecular Weight (kDa): 106.999
UniProt ID(s): Q8IL32
Isoelectric Point: 5.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001404 | Heat shock protein Hsp90 family |
| InterPro | IPR019805 | Heat shock protein Hsp90, conserved site |
| InterPro | IPR020568 | Ribosomal protein S5 domain 2-type fold |
| InterPro | IPR020575 | Heat shock protein Hsp90, N-terminal |
| InterPro | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
| InterPro | IPR037196 | HSP90, C-terminal domain |
| PFam | PF00183 | Heat shock protein Hsp90 family |
| PFam | PF13589 | |
| Superfamily | SSF110942 | HSP90, C-terminal domain |
| Superfamily | SSF54211 | Ribosomal protein S5 domain 2-type fold |
| Superfamily | SSF55874 | Histidine kinase/HSP90-like ATPase superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20140477 | Characterization of Plasmodium falciparum co-chaperone p23: its intrinsicchaperone activity and interaction with Hsp90. | Chua CS, Low H, Goo KS, Sim TS | 10.1007/s00018-010-0275-0 |
| 20635416 | Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. | Corbett KD, Berger JM | 10.1002/prot.22799 |
| 20719001 | Chaperone expression profiles correlate with distinct physiological states ofPlasmodium falciparum in malaria patients. | Pallavi R, Acharya P, ..., Tatu U | 10.1186/1475-2875-9-236 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 38411135 | The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy | Backe SJ, Heritz JA, Mollapour M | 10.1080/15548627.2024.2323259 |
| 38394204 | HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer | Chen F, Tang C, ..., Teng Y | 10.1126/sciadv.adk3663 |
| 38411361 | JD-02, a novel Hsp90 inhibitor, induces ROS/SRC axis-dependent cytoprotectiveautophagy in colorectal cancer cells | Lan N, Su Y, ..., Liu K | 10.1002/mc.23706 |
| 38396983 | Genome-Wide Analysis of the Oat (Avena sativa) HSP90 Gene Family Reveals Its Identification, Evolution, and Response to Abiotic Stress | Peng J, Liu S, ..., Ma X | 10.3390/ijms25042305 |
| 38389899 | Insights into Hsp90 mechanism and in vivo functions learned from studies in theyeast, Saccharomyces cerevisiae | Rios EI, Hunsberger IL, Johnson JL | 10.3389/fmolb.2024.1325590 |