PF3D7_1444000

Genome location: Pf3D7_14_v3:1,800,831..1,801,887(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1444000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.395 | MFS: -3.332 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1307900)

Relative Growth Rate: 1.01 ± 0.11
Confidence: 5.76

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1307900)

Modification: Disrupted | RMgm-4275

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL31

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533250

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	13	8	15
disruptive	9	34	20	57
missense	9	34	20	54

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	19	15	13
disruptive	14	76	28	58
missense	13	69	25	48

PlasmoDB Total SNPs: 58

Non-coding: 45 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 227 | Molecular Weight (kDa): 28.252

UniProt ID(s): Q8IL31

PDB ID(s): None

Isoelectric Point: 10.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A