PF3D7_1444100

Genome location: Pf3D7_14_v3:1,801,961..1,825,635(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.20	0.91
Trophozoite	possibly expressed	0.49	0.75
Schizont	possibly expressed	1.14	0.50
Gametocyte	not expressed	1.34	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1444100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.814 | #Insertions: 36

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102723

Most Similar Human Ortholog: Not available

TM-align score: 0.00 | RMSD: 0.00

Seq Identity: 0.00 | Length: / 7231

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000157423	HYDIN axonemal central pair apparatus protein
ENSG00000283022	HYDIN axonemal central pair apparatus protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	70	346	184	447
disruptive	219	1177	657	1439
missense	173	1087	629	1321

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	105	663	280	495
disruptive	465	2264	919	1687
missense	335	2033	837	1444

PlasmoDB Total SNPs: 958

Non-coding: 302 | Synonymous: 333 | Nonsynonymous: 322 | Stop Codon: 1

Protein Information

Protein Length: 7231 | Molecular Weight (kDa): 865.03

UniProt ID(s): Q8IL30

PDB ID(s): None

Isoelectric Point: 8.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR033305	Hydrocephalus-inducing-like
PFam	N/A	N/A
Superfamily	N/A	N/A