Product Description: EF-hand calcium-binding domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | expressed | 0.18 | 0.88 |
| Gametocyte | not expressed | 0.36 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1444200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.531 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL29
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 6 | 11 | 13 |
| disruptive | 0 | 4 | 9 | 22 |
| missense | 0 | 4 | 9 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 21 | 9 | 19 |
| disruptive | 2 | 31 | 22 | 77 |
| missense | 1 | 18 | 18 | 49 |
PlasmoDB Total SNPs: 96
Non-coding: 91 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 207 | Molecular Weight (kDa): 24.954
UniProt ID(s): Q8IL29
PDB ID(s): None
Isoelectric Point: 7.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| InterPro | IPR039647 | EF-hand domain pair protein CML-like |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34956931 | Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening ofPlasmodium falciparum. | Hou N, Li S, ..., Chen Q | https://pubmed.ncbi.nlm.nih.gov/34956931/ |