PF3D7_1444400

Genome location: Pf3D7_14_v3:1,830,874..1,833,717(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.17	0.90
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1444400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.034 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL27

"Best" AlphaFill ligand hit: A2P (adenosine-2'-5'-diphosphate, Local RMSD=0.30) with 3JQP (Global RMSD=17.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533512

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	19	21	33
disruptive	14	72	34	79
missense	14	72	33	78

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	42	17	38
disruptive	30	141	55	126
missense	28	129	52	102

PlasmoDB Total SNPs: 143

Non-coding: 114 | Synonymous: 11 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 503 | Molecular Weight (kDa): 61.294

UniProt ID(s): Q8IL27

PDB ID(s): None

Isoelectric Point: 7.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A