About Gene List

PF3D7_1444700

Genome location: Pf3D7_14_v3:1,841,602..1,843,256(+)

Genome classification: Core

Function and Localization

Product Description: shikimate dehydrogenase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: 1.1.1.25 (Shikimate dehydrogenase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite possibly expressed 0.13 0.91
Schizont possibly expressed 0.02 0.98
Gametocyte not expressed 0.04 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1444700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.486 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL25

"Best" AlphaFill ligand hit: T3F (thymidine-5'-diphosphate-alpha-d-3,6-dideoxy-3-aminogalactose, Local RMSD=3.53) with 7N7B (Global RMSD=20.15)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
1.1.1.25 shikimate dehydrogenase (NADP+) SDSNH4+NADP+HgCl2CuSO4ZnCl2CdSO4Borateebselenlimoninguaiacolarsenite...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532314

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 8 5 16
disruptive 2 14 9 32
missense 2 14 9 32

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 19 9 15
disruptive 4 38 23 49
missense 3 36 18 44

PlasmoDB Total SNPs: 87

Non-coding: 79 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 186 | Molecular Weight (kDa): 21.997

UniProt ID(s): Q8IL25

PDB ID(s): None

Isoelectric Point: 9.84

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094