PF3D7_1444900

Genome location: Pf3D7_14_v3:1,847,896..1,848,877(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.12	0.94
Trophozoite	expressed	0.44	0.75
Schizont	possibly expressed	0.04	0.97
Gametocyte	expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1444900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.429 | MFS: -2.413 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL24

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533355

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	8	2	8
disruptive	1	23	14	34
missense	1	22	13	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	12	5	9
disruptive	7	67	28	48
missense	2	51	23	30

PlasmoDB Total SNPs: 36

Non-coding: 22 | Synonymous: 7 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 172 | Molecular Weight (kDa): 21.01

UniProt ID(s): Q8IL24

PDB ID(s): None

Isoelectric Point: 10.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A