PF3D7_1445000

Genome location: Pf3D7_14_v3:1,849,172..1,850,395(-)

Genome classification: Core

Function and Localization

Product Description: prolyl hydroxylase-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.33	0.80
Schizont	expressed	0.33	0.79
Gametocyte	expressed	0.39	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1445000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.171 | MFS: -2.668 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL23

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_124625

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	19	13	33
disruptive	9	45	28	52
missense	9	44	27	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	35	25	36
disruptive	15	97	44	86
missense	14	92	39	59

PlasmoDB Total SNPs: 17

Non-coding: 3 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 406 | Molecular Weight (kDa): 48

UniProt ID(s): Q8IL23

PDB ID(s): None

Isoelectric Point: 6.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A