PF3D7_1445300

Genome location: Pf3D7_14_v3:1,859,926..1,862,497(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S29, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005763	mitochondrial small ribosomal subunit
Component	GO:0005739	mitochondrion
Function	GO:0003735	structural constituent of ribosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.05	0.97
Trophozoite	expressed	0.27	0.83
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1445300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.888 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1309100)

Relative Growth Rate: 0.11 ± 0.06
Confidence: 7.01

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL20

"Best" AlphaFill ligand hit: VIB (3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium, Local RMSD=13.47) with 4KYS (Global RMSD=17.50)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122553

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	35	25	41
disruptive	21	83	50	87
missense	17	83	49	83

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	79	32	32
disruptive	38	147	67	128
missense	32	141	61	100

PlasmoDB Total SNPs: 141

Non-coding: 99 | Synonymous: 22 | Nonsynonymous: 18 | Stop Codon: 2

Protein Information

Protein Length: 604 | Molecular Weight (kDa): 72.303

UniProt ID(s): Q8IL20

PDB ID(s): None

Isoelectric Point: 9.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019368	Ribosomal protein S23/S29, mitochondrial
PFam	PF10236	Ribosomal protein S23/S29, mitochondrial
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21