PF3D7_1445500

Genome location: Pf3D7_14_v3:1,866,106..1,868,844(+)

Genome classification: Core

Function and Localization

Product Description: exosome-associated factor Rrp47, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0000178	exosome (RNase complex)
Component	GO:0005730	nucleolus
Function	GO:0003677	DNA binding
Function	GO:0003723	RNA binding
Process	GO:0000460	maturation of 5.8S rRNA
Process	GO:0010468	regulation of gene expression

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.22	0.89
Trophozoite	possibly expressed	0.20	0.88
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.17	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1445500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.369 | MFS: -3.298 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL18

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=1.25) with 4RKZ (Global RMSD=24.26)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103626

Most Similar Human Ortholog: Q13901

TM-align score: 0.65 | RMSD: 2.39

Seq Identity: 0.21 | Length: 105 / 149

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000197223	C1D nuclear receptor corepressor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 86

Non-coding: 83 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 149 | Molecular Weight (kDa): 17.31

UniProt ID(s): Q8IL18

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007146	Sas10/Utp3/C1D
InterPro	IPR011082	Exosome-associated factor Rrp47/DNA strand repair C1D
PFam	PF04000	Sas10/Utp3/C1D
Superfamily	N/A	N/A