PF3D7_1445600

Genome location: Pf3D7_14_v3:1,869,893..1,874,662(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.76	0.64
Trophozoite	expressed	0.40	0.76
Schizont	expressed	0.35	0.77
Gametocyte	expressed	0.45	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1445600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.962 | MFS: 0.487 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1309400)

Relative Growth Rate: 0.04 ± 0.03
Confidence: 8.22

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL17

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_142426

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	40	17	44
disruptive	20	106	42	121
missense	19	100	39	112

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	78	27	41
disruptive	47	189	89	220
missense	40	174	72	143

PlasmoDB Total SNPs: 281

Non-coding: 220 | Synonymous: 35 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 596 | Molecular Weight (kDa): 69.349

UniProt ID(s): Q8IL17

PDB ID(s): None

Isoelectric Point: 8.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR012921	Spen paralogue and orthologue SPOC, C-terminal
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
PFam	PF07744	Spen paralogue and orthologue SPOC, C-terminal
Superfamily	SSF54928	RNA-binding domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108