About Gene List

PF3D7_1445700

Genome location: Pf3D7_14_v3:1,875,378..1,877,731(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0005829 cytosol
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.89 0.59
Trophozoite expressed 0.90 0.53
Schizont expressed 0.17 0.89
Gametocyte expressed 0.73 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1445700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.222 | MFS: -2.639 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL16

"Best" AlphaFill ligand hit: T3F (thymidine-5'-diphosphate-alpha-d-3,6-dideoxy-3-aminogalactose, Local RMSD=0.95) with 7N7B (Global RMSD=28.17)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532715

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 22 17 31
disruptive 3 17 14 35
missense 3 17 14 33

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 47 23 23
disruptive 4 52 27 71
missense 4 43 26 55

PlasmoDB Total SNPs: 114

Non-coding: 101 | Synonymous: 10 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 351 | Molecular Weight (kDa): 41.934

UniProt ID(s): Q8IL16

PDB ID(s): None

Isoelectric Point: 9.83

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
16337634 Maurer's clefts: a novel multi-functional organelle in the cytoplasm ofPlasmodium falciparum-infected erythrocytes. Lanzer M, Wickert H, ..., Braun Breton C 10.1016/j.ijpara.2005.10.001
28288121 A genetic system to study Plasmodium falciparum protein function. Birnbaum J, Flemming S, ..., Spielmann T 10.1038/nmeth.4223