PF3D7_1445800

Genome location: Pf3D7_14_v3:1,878,658..1,882,577(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 13

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.07	0.95
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1445800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.887 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1309600)

Relative Growth Rate: 0.83 ± 0.39
Confidence: 3.28

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1309600)

Modification: Disrupted | RMgm-4276

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL15

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532431

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	71	49	94
disruptive	29	119	73	185
missense	22	111	70	169

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	123	73	74
disruptive	51	296	115	269
missense	34	254	100	206

PlasmoDB Total SNPs: 102

Non-coding: 16 | Synonymous: 54 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 1207 | Molecular Weight (kDa): 144.903

UniProt ID(s): Q8IL15

PDB ID(s): None

Isoelectric Point: 8.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097