PF3D7_1446100

Genome location: Pf3D7_14_v3:1,889,978..1,892,108(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.45	0.79
Trophozoite	possibly expressed	0.14	0.92
Schizont	not expressed	0.18	0.89
Gametocyte	expressed	0.86	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1446100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.042 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1309800)

Relative Growth Rate: 0.97 ± 0.15
Confidence: 5.21

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1309800)

Modification: Disrupted | RMgm-3451

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL12

"Best" AlphaFill ligand hit: SRT (s,r meso-tartaric acid, Local RMSD=0.70) with 4O3V (Global RMSD=20.62)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533237

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	39	28	53
disruptive	25	118	82	168
missense	21	109	78	146

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	74	41	53
disruptive	57	263	117	214
missense	39	236	101	144

PlasmoDB Total SNPs: 73

Non-coding: 8 | Synonymous: 32 | Nonsynonymous: 32 | Stop Codon: 1

Protein Information

Protein Length: 670 | Molecular Weight (kDa): 80.611

UniProt ID(s): Q8IL12

PDB ID(s): None

Isoelectric Point: 10.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A