Genome location: Pf3D7_14_v3:1,906,176..1,916,570(+)
Genome classification: Core
Product Description: nucleoporin NUP313, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005643 | nuclear pore |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.77 | 0.33 |
| Trophozoite | expressed | 1.93 | 0.20 |
| Schizont | expressed | 0.85 | 0.58 |
| Gametocyte | possibly expressed | 1.58 | 0.28 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1446500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.99 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1314100)
Modification: Tagged | RMgm-5300
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 142 | 80 | 183 |
| disruptive | 122 | 381 | 234 | 498 |
| missense | 69 | 323 | 220 | 434 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 33 | 285 | 126 | 199 |
| disruptive | 204 | 776 | 354 | 724 |
| missense | 116 | 664 | 299 | 518 |
PlasmoDB Total SNPs: 455
Non-coding: 92 | Synonymous: 191 | Nonsynonymous: 172 | Stop Codon: 0
Protein Length: 3001 | Molecular Weight (kDa): 346.92
UniProt ID(s): Q8IL08
PDB ID(s): None
Isoelectric Point: 9.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR025574 | Nucleoporin FG repeat |
| PFam | PF13634 | Nucleoporin FG repeat |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30050042 | Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei. | Kehrer J, Kuss C, ..., Frischknecht F | 10.1038/s41598-018-29590-5 |
| 38405843 | Nuclear pore complexes undergo Nup221 exchange during blood stage asexualreplication of Plasmodium parasites | Blauwkamp JA, Ambekar SV, ..., Absalon S | 10.1101/2024.02.16.580747 |