Genome location: Pf3D7_14_v3:1,916,768..1,918,572(-)
Genome classification: Core
Product Description: centrin-2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005814 | centriole |
| Component | GO:0005813 | centrosome |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005509 | calcium ion binding |
| Process | GO:0007099 | centriole replication |
| Process | GO:0000278 | mitotic cell cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.75 | 0.59 |
| Schizont | expressed | 1.05 | 0.45 |
| Gametocyte | expressed | 0.96 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1446600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.804 | MFS: -2.081 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1310400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL07
"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=0.07) with 5I0I (Global RMSD=8.56)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101416
Most Similar Human Ortholog: P41208
TM-align score: 0.42 | RMSD: 2.56
Seq Identity: 0.61 | Length: 78 / 168
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000147400 | centrin 2 |
| ENSG00000177143 | centrin 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 72
Non-coding: 65 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 168 | Molecular Weight (kDa): 19.311
UniProt ID(s): Q8IL07
PDB ID(s): None
Isoelectric Point: 4.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18693242 | Centrins, cell cycle regulation proteins in human malaria parasite Plasmodiumfalciparum. | Mahajan B, Selvapandiyan A, ..., Kumar S | 10.1074/jbc.M800028200 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 24336221 | Dynamics of yeast histone H2A and H2B phosphorylation in response to adouble-strand break | Lee CS, Lee K, Legube G, Haber JE | 10.1038/nsmb.2737 |
| 28700723 | Position effects influencing intrachromosomal repair of a double-strand break inbudding yeast | Wang RW, Lee CS, Haber JE | 10.1371/journal.pone.0180994 |
| 31182647 | Centrin2 from the human parasite Toxoplasma gondii is required for its invasionand intracellular replication | Leung JM, Liu J, Wetzel LA, Hu K | 10.1242/jcs.228791 |
| 27560164 | Novel Centromeric Loci of the Wine and Beer Yeast Dekkera bruxellensis CEN1 andCEN2 | Ishchuk OP, Vojvoda Zeljko T, ..., Piskur J | 10.1371/journal.pone.0161741 |
| 31206964 | The roles of Centrin 2 and Dynein Light Chain 8a in apical secretory organellesdischarge of Toxoplasma gondii | Lentini G, Dubois DJ, ..., Frenal K | 10.1111/tra.12673 |