Product Description: 40S ribosomal protein S5
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.42 | 0.41 |
| Trophozoite | expressed | 1.78 | 0.25 |
| Schizont | expressed | 0.37 | 0.78 |
| Gametocyte | expressed | 0.97 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1447000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.659 | MFS: -2.107 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1310800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL02
"Best" AlphaFill ligand hit: SCM (actinospectacin, Local RMSD=0.25) with 1FJG (Global RMSD=2.19)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100429
Most Similar Human Ortholog: I3L404
TM-align score: 0.98 | RMSD: 0.68
Seq Identity: 0.72 | Length: 155 / 272
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000140988 | ribosomal protein S2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 12 | 12 |
| disruptive | 0 | 3 | 0 | 17 |
| missense | 0 | 3 | 0 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 28 | 10 | 12 |
| disruptive | 2 | 13 | 16 | 55 |
| missense | 1 | 8 | 12 | 41 |
PlasmoDB Total SNPs: 138
Non-coding: 129 | Synonymous: 4 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 272 | Molecular Weight (kDa): 29.958
UniProt ID(s): Q8IL02
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000851 | Ribosomal protein S5 |
| InterPro | IPR005324 | Ribosomal protein S5, C-terminal |
| InterPro | IPR005711 | Ribosomal protein S5, eukaryotic/archaeal |
| InterPro | IPR013810 | Ribosomal protein S5, N-terminal |
| InterPro | IPR020568 | Ribosomal protein S5 domain 2-type fold |
| PFam | PF00333 | Ribosomal protein S5, N-terminal |
| PFam | PF03719 | Ribosomal protein S5, C-terminal |
| Superfamily | SSF54211 | Ribosomal protein S5 domain 2-type fold |
| Superfamily | SSF54768 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |