PF3D7_1447100

Genome location: Pf3D7_14_v3:1,931,917..1,933,434(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.47	0.77
Trophozoite	expressed	0.31	0.81
Schizont	possibly expressed	0.11	0.93
Gametocyte	expressed	0.33	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1447100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.075 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1310900)

Modification: Other | RMgm-465

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IL01

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532316

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	3	7
disruptive	3	28	19	24
missense	2	28	16	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	21	5	6
disruptive	14	63	18	38
missense	9	48	13	26

PlasmoDB Total SNPs: 83

Non-coding: 66 | Synonymous: 8 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 144 | Molecular Weight (kDa): 17.125

UniProt ID(s): Q8IL01

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A