PF3D7_1447300

Genome location: Pf3D7_14_v3:1,936,324..1,937,700(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S14, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005763	mitochondrial small ribosomal subunit
Component	GO:0005739	mitochondrion
Component	GO:0015935	small ribosomal subunit
Function	GO:0003735	structural constituent of ribosome
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.00	1.00
Gametocyte	possibly expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1447300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.194 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1311100)

Relative Growth Rate: 0.10 ± 0.10
Confidence: 6.04

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I6V1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_137732

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	11	6	6
disruptive	1	2	2	14
missense	1	2	2	13

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	20	1	7
disruptive	2	9	6	25
missense	2	7	3	19

PlasmoDB Total SNPs: 46

Non-coding: 39 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 112 | Molecular Weight (kDa): 13.321

UniProt ID(s): Q8I6V1

PDB ID(s): None

Isoelectric Point: 11.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001209	Ribosomal protein S14
PFam	N/A	N/A
Superfamily	SSF57716	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21