PF3D7_1447600

Genome location: Pf3D7_14_v3:1,942,151..1,942,963(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MKGIAFRLFVFVLFFYITNYNVIYG

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1447600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.256 | MFS: -2.412 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1311400)

Relative Growth Rate: 1.02 ± 0.13
Confidence: 5.48

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1315200)

Modification: Disrupted | RMgm-4790

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3I9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179358

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	7	0	11
disruptive	3	9	5	21
missense	3	9	4	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	13	6	3
disruptive	3	35	16	28
missense	3	32	13	24

PlasmoDB Total SNPs: 23

Non-coding: 13 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 121 | Molecular Weight (kDa): 14.004

UniProt ID(s): C6S3I9

PDB ID(s): None

Isoelectric Point: 8.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A