PF3D7_1447700

Genome location: Pf3D7_14_v3:1,943,918..1,945,580(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.20	0.87
Schizont	not expressed	0.14	0.90
Gametocyte	possibly expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1447700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.051 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1311500)

Relative Growth Rate: 0.99 ± 0.14
Confidence: 5.39

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1311500)

Modification: Disrupted | RMgm-4629

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKZ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108921

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	17	10	26
disruptive	2	20	12	24
missense	2	20	12	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	38	15	32
disruptive	6	45	31	49
missense	5	33	26	32

PlasmoDB Total SNPs: 107

Non-coding: 77 | Synonymous: 25 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 342 | Molecular Weight (kDa): 40.695

UniProt ID(s): Q8IKZ8

PDB ID(s): None

Isoelectric Point: 9.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
33906926	Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH	Sinha A, Baumgarten S, ..., Scherf A	10.1128/mBio.00661-21