PF3D7_1447800

Genome location: Pf3D7_14_v3:1,946,965..1,953,556(+)

Genome classification: Core

Function and Localization

Product Description: calponin homology domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.29	0.86
Trophozoite	not expressed	0.51	0.72
Schizont	not expressed	0.30	0.82
Gametocyte	not expressed	0.92	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1447800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.679 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKZ7

"Best" AlphaFill ligand hit: G3D (guanosine-3'-monophosphate-5'-diphosphate, Local RMSD=0.03) with 3KB2 (Global RMSD=17.95)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125595

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	21	77	50	130
disruptive	140	328	181	416
missense	66	250	145	311

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	178	62	157
disruptive	229	633	278	538
missense	116	457	224	380

PlasmoDB Total SNPs: 336

Non-coding: 46 | Synonymous: 127 | Nonsynonymous: 163 | Stop Codon: 0

Protein Information

Protein Length: 1986 | Molecular Weight (kDa): 238.05

UniProt ID(s): Q8IKZ7

PDB ID(s): None

Isoelectric Point: 6.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036872	CH domain superfamily
PFam	N/A	N/A
Superfamily	SSF47576	CH domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104