PF3D7_1448000 (UTP12)

Genome location: Pf3D7_14_v3:1,959,368..1,964,665(-)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar RNA-associated protein 12, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome
Component	GO:0005730	nucleolus
Component	GO:0032040	small-subunit processome
Function	GO:0030515	snoRNA binding
Process	GO:0030490	maturation of SSU-rRNA

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.46	0.78
Trophozoite	expressed	0.37	0.79
Schizont	possibly expressed	0.08	0.95
Gametocyte	possibly expressed	0.39	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1448000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.847 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKZ5

"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.01) with 6Y7O (Global RMSD=2.65)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102330

Most Similar Human Ortholog: Q9UNX4

TM-align score: 0.87 | RMSD: 3.13

Seq Identity: 0.27 | Length: 876 / 1275

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000065183	WD repeat domain 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	59	33	85
disruptive	35	152	81	190
missense	28	139	76	171

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	110	45	91
disruptive	71	301	115	306
missense	51	267	101	251

PlasmoDB Total SNPs: 204

Non-coding: 106 | Synonymous: 57 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 1275 | Molecular Weight (kDa): 149.319

UniProt ID(s): Q8IKZ5

PDB ID(s): None

Isoelectric Point: 5.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
InterPro	IPR019775	WD40 repeat, conserved site
PFam	PF00400	WD40 repeat
Superfamily	SSF101908	Quinoprotein alcohol dehydrogenase-like superfamily
Superfamily	SSF50998