Genome location: Pf3D7_14_v3:1,966,245..1,971,618(-)
Genome classification: Core
Product Description: condensin-2 complex subunit G2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000796 | condensin complex |
| Component | GO:0005634 | nucleus |
| Process | GO:0000070 | mitotic sister chromatid segregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.03 | 0.98 |
| Schizont | not expressed | 0.02 | 0.98 |
| Gametocyte | not expressed | 0.36 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1448200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.452 | #Insertions: 4
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1312000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1312000)
Modification: Disrupted | RMgm-3463
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKZ3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 56 | 34 | 93 |
| disruptive | 36 | 134 | 80 | 185 |
| missense | 27 | 119 | 74 | 160 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 100 | 67 | 93 |
| disruptive | 71 | 277 | 132 | 302 |
| missense | 48 | 240 | 110 | 226 |
PlasmoDB Total SNPs: 334
Non-coding: 234 | Synonymous: 62 | Nonsynonymous: 38 | Stop Codon: 0
Protein Length: 1206 | Molecular Weight (kDa): 145.454
UniProt ID(s): Q8IKZ3
PDB ID(s): None
Isoelectric Point: 8.19
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR024741 | Condensin-2 complex subunit G2 |
| PFam | PF12422 | Condensin-2 complex subunit G2 |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32049018 | Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and AreEssential for Parasite Proliferation and Transmission. | Pandey R, Abel S, ..., Tewari R | 10.1016/j.celrep.2020.01.033 |