Genome location: Pf3D7_14_v3:1,979,973..1,983,139(-)
Genome classification: Core
Product Description: ubiquitin-protein ligase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 6.3.2.19 (Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Function | GO:0008047 | enzyme activator activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.10 | 0.95 |
Trophozoite | expressed | 0.73 | 0.59 |
Schizont | expressed | 0.38 | 0.77 |
Gametocyte | expressed | 0.83 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1448400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.853 | MFS: -2.717 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKY9
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
6.3.2.19 | ubiquitin-protein ligase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101047
Most Similar Human Ortholog: A0A2R8Y3T2
TM-align score: 0.84 | RMSD: 3.26
Seq Identity: 0.25 | Length: 381 / 851
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000071537 | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase |
ENSG00000101251 | SEL1L2 adaptor subunit of ERAD E3 ligase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 41 | 30 | 72 |
disruptive | 13 | 61 | 36 | 112 |
missense | 13 | 56 | 33 | 88 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 13 | 82 | 38 | 94 |
disruptive | 29 | 149 | 69 | 193 |
missense | 18 | 125 | 60 | 124 |
PlasmoDB Total SNPs: 81
Non-coding: 43 | Synonymous: 26 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 851 | Molecular Weight (kDa): 100.446
UniProt ID(s): Q8IKY9
PDB ID(s): None
Isoelectric Point: 9.19
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR006597 | Sel1-like repeat |
PFam | PF08238 | Sel1-like repeat |
Superfamily | SSF81901 | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
26184977 | Analysis of antibody production in Saccharomyces cerevisiae: effects of ERprotein quality control disruption | de Ruijter JC, Frey AD | 10.1007/s00253-015-6807-7 |