PF3D7_1448500

Genome location: Pf3D7_14_v3:1,983,780..1,996,262(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.1.1.37 (DNA (cytosine-5-)-methyltransferase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.30	0.87
Trophozoite	expressed	1.92	0.25
Schizont	expressed	2.01	0.27
Gametocyte	expressed	1.56	0.34

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1448500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.164 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.1.1.37	DNA (cytosine-5-)-methyltransferase	KClEDTA2'-dCRG108enolasesperminecurcuminNicotineprocainemiR-9-3pmiR-9-5pNSC 14778...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130183

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	39	168	112	226
disruptive	257	728	341	799
missense	204	621	303	666

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	65	341	166	254
disruptive	453	1342	520	981
missense	338	1111	430	715

PlasmoDB Total SNPs: 791

Non-coding: 149 | Synonymous: 297 | Nonsynonymous: 345 | Stop Codon: 0

Protein Information

Protein Length: 3704 | Molecular Weight (kDa): 443.073

UniProt ID(s): Q8IKY8, Q8WSM8, Q968T6, Q968T7, Q968Y0

PDB ID(s): None

Isoelectric Point: 8.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022702	DNA (cytosine-5)-methyltransferase 1, replication foci domain
PFam	PF12047	DNA (cytosine-5)-methyltransferase 1, replication foci domain
Superfamily	SSF57997	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108