Genome location: Pf3D7_14_v3:1,997,036..1,998,336(-)
Genome classification: Core
Product Description: SNARE protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0031201 | SNARE complex |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0031902 | late endosome membrane |
| Function | GO:0005484 | SNAP receptor activity |
| Function | GO:0000149 | SNARE binding |
| Process | GO:0006896 | Golgi to vacuole transport |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Process | GO:0006623 | protein targeting to vacuole |
| Process | GO:0031338 | regulation of vesicle fusion |
| Process | GO:0042147 | retrograde transport, endosome to Golgi |
| Process | GO:0048280 | vesicle fusion with Golgi apparatus |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.20 | 0.90 |
| Trophozoite | not expressed | 0.37 | 0.77 |
| Schizont | not expressed | 0.17 | 0.88 |
| Gametocyte | expressed | 0.92 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1448600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.145 | MFS: -2.594 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1312300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKY7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 9 | 16 |
| disruptive | 5 | 26 | 18 | 35 |
| missense | 5 | 26 | 18 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 24 | 13 | 19 |
| disruptive | 8 | 61 | 41 | 65 |
| missense | 8 | 56 | 32 | 43 |
PlasmoDB Total SNPs: 93
Non-coding: 70 | Synonymous: 16 | Nonsynonymous: 7 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30080296 | Yeast dynamin and Ypt6 function in parallel for the endosome-to-Golgi retrievalof Snc1 | Makaraci P, Delgado Cruz M, ..., Kim K | 10.1002/cbin.11042 |
| 25512335 | Btn3 regulates the endosomal sorting function of the yeast Ent3 epsin, an adaptorfor SNARE proteins | Morvan J, de Craene JO, ..., Friant S | 10.1242/jcs.159699 |
| 27385334 | Improved reconstitution of yeast vacuole fusion with physiological SNAREconcentrations reveals an asymmetric Rab(GTP) requirement | Zick M, Wickner W | 10.1091/mbc.E16-04-0230 |
| 21441304 | Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking andprion curing in yeast | Kanneganti V, Kama R, Gerst JE | 10.1091/mbc.E10-11-0878 |
| 23776654 | Importance of the N-terminal domain of the Qb-SNARE Vti1p for different membranetransport steps in the yeast endosomal system | Gossing M, Chidambaram S, Fischer von Mollard G | 10.1371/journal.pone.0066304 |
| 19076069 | TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrogradetransport from the early endosome to the late Golgi | Stein IS, Gottfried A, Zimmermann J, Fischer von Mollard G | 10.1042/BJ20081973 |