PF3D7_1448700

Genome location: Pf3D7_14_v3:1,999,072..2,000,982(+)

Genome classification: Core

Function and Localization

Product Description: HSP20-like chaperone, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.14	0.93
Trophozoite	possibly expressed	0.15	0.91
Schizont	possibly expressed	0.04	0.97
Gametocyte	expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1448700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.121 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKY6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156428

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	16	10	21
disruptive	14	58	35	81
missense	12	54	33	68

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	37	10	21
disruptive	28	121	56	122
missense	23	109	47	69

PlasmoDB Total SNPs: 126

Non-coding: 86 | Synonymous: 21 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 333 | Molecular Weight (kDa): 39.461

UniProt ID(s): Q8IKY6

PDB ID(s): None

Isoelectric Point: 7.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008978	HSP20-like chaperone
PFam	N/A	N/A
Superfamily	SSF49764	HSP20-like chaperone