Genome location: Pf3D7_14_v3:2,002,360..2,003,426(-)
Genome classification: Core
Product Description: mitochondrial respiratory chain complex II subunit, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) |
| Component | GO:0045273 | respiratory chain complex II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.01 | 0.99 |
| Trophozoite | no data | 0.09 | 0.94 |
| Schizont | no data | 0.02 | 0.99 |
| Gametocyte | no data | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1448900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.144 | MFS: -2.865 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1312600)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1312600)
Modification: Disrupted | RMgm-4621
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3J0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 2 | 0 | 8 |
| disruptive | 0 | 7 | 5 | 7 |
| missense | 0 | 7 | 5 | 7 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 3 | 10 |
| disruptive | 1 | 14 | 4 | 13 |
| missense | 1 | 13 | 4 | 13 |
PlasmoDB Total SNPs: 68
Non-coding: 58 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 75 | Molecular Weight (kDa): 8.922
UniProt ID(s): C6S3J0
PDB ID(s): None
Isoelectric Point: 10.54
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 33651838 | Complexome profile of Toxoplasma gondii mitochondria identifies divergentsubunits of respiratory chain complexes including new subunits of cytochrome bc1complex. | Maclean AE, Bridges HR, ..., Sheiner L | 10.1371/journal.ppat.1009301 |
| 34155201 | Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. | Evers F, Cabrera-Orefice A, ..., Kooij TWA | 10.1038/s41467-021-23919-x |
| 38079448 | Functional and biochemical characterization of the Toxoplasma gondii succinatedehydrogenase complex | Silva MF, Douglas K, ..., Sheiner L | 10.1371/journal.ppat.1011867 |