Genome location: Pf3D7_14_v3:2,004,406..2,005,456(-)
Genome classification: Core
Product Description: gamete egress and sporozoite traversal protein, putative
SignalP Peptide: MNKFTYCITLLIALVLPIRS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0020009 | microneme |
| Component | GO:0044310 | osmiophilic body |
| Process | GO:0035891 | exit from host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.01 | 1.00 |
| Schizont | possibly expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.34 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1449000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.998 | MFS: -1.4 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1312700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1312700)
Modification: Disrupted | RMgm-3467
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKY4
"Best" AlphaFill ligand hit: STE (stearic acid, Local RMSD=0.59) with 5UWZ (Global RMSD=24.16)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 5 | 7 | 8 |
| disruptive | 25 | 26 | 11 | 43 |
| missense | 23 | 24 | 11 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 15 | 8 | 16 |
| disruptive | 29 | 46 | 21 | 72 |
| missense | 27 | 42 | 21 | 51 |
PlasmoDB Total SNPs: 61
Non-coding: 36 | Synonymous: 2 | Nonsynonymous: 23 | Stop Codon: 0
Protein Length: 248 | Molecular Weight (kDa): 28.765
UniProt ID(s): Q8IKY4
PDB ID(s): None
Isoelectric Point: 9.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21958024 | PbGEST mediates malaria transmission to both mosquito and vertebrate host. | Talman AM, Lacroix C, ..., Sinden RE | 10.1111/j.1365-2958.2011.07823.x |
| 26292257 | Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. | Aguiar JC, Bolton J, ..., Richie TL | 10.1371/journal.pone.0136109 |
| 27432909 | Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodiumfalciparum Osmiophilic Bodies in Malaria Parasite Transmission. | Suarez-Cortes P, Sharma V, ..., Alano P | 10.1074/mcp.M116.060681 |
| 28759593 | Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodiumvivax salivary gland sporozoites. | Swearingen KE, Lindner SE, ..., Mikolajczak SA | https://pubmed.ncbi.nlm.nih.gov/28759593/ |